藥物交互作用
Nevirapine + St john's wort
嚴重程度: 禁忌併用
Nevirapine and St john's wort: contraindicated interaction.
最後更新
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摘要
St John's wort can substantially lower nevirapine concentrations, which may lead to virologic failure and resistance. Nevirapine's resistance barrier is low.
用白話說明這項交互作用的意義
Nevirapine and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
St John's wort induces CYP3A4 and CYP2B6 and P-glycoprotein, increasing nevirapine clearance.
處置方式
Do not use together. If St John's wort was used, stop it and monitor HIV RNA, noting that enzyme induction fades over about two weeks.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Nevirapine 的其他交互作用
常見問題
Can I take Nevirapine with St john's wort?
MediHelp rates the interaction as contraindicated. Nevirapine and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. St John's wort can substantially lower nevirapine concentrations, which may lead to virologic failure and resistance. Nevirapine's resistance barrier is low.
How serious is the interaction between Nevirapine and St john's wort?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. If St John's wort was used, stop it and monitor HIV RNA, noting that enzyme induction fades over about two weeks.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, Abemaciclib. The full list is on the Nevirapine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
