藥物交互作用
Tiotropium + Umeclidinium bromide / vilanterol inhaled
嚴重程度: 嚴重
Tiotropium and Umeclidinium bromide / vilanterol inhaled: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both tiotropium and umeclidinium are long-acting inhaled antimuscarinics, so combining them duplicates therapy. This increases anticholinergic effects such as dry mouth, urinary retention, constipation, tachycardia and worsening narrow-angle glaucoma without added benefit.
用白話說明這項交互作用的意義
Tiotropium and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Duplicate long-acting muscarinic antagonism producing additive anticholinergic effects.
處置方式
Avoid concurrent use and keep only one long-acting antimuscarinic. Stop one product and monitor for anticholinergic effects if the combination was used.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Tiotropium 的其他交互作用
常見問題
Can I take Tiotropium with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as major. Tiotropium and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both tiotropium and umeclidinium are long-acting inhaled antimuscarinics, so combining them duplicates therapy. This increases anticholinergic effects such as dry mouth, urinary retention, constipation, tachycardia and worsening narrow-angle glaucoma without added benefit.
How serious is the interaction between Tiotropium and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep only one long-acting antimuscarinic. Stop one product and monitor for anticholinergic effects if the combination was used.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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