Drug interactions
Lonafarnib + Lorlatinib
Severity: Contraindicated
Lonafarnib and Lorlatinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4, and lonafarnib is a sensitive CYP3A4 substrate. Lowered lonafarnib exposure may reduce its benefit, and labeling contraindicates its use with CYP3A inducers.
What this interaction means in plain words
Lonafarnib and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lonafarnib belongs to Miscellaneous; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4 and speeds lonafarnib metabolism.
What to do
Avoid the combination and consider an alternative to lorlatinib. Seek specialist advice if both are essential.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Lorlatinib?
MediHelp rates the interaction as contraindicated. Lonafarnib and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lorlatinib induces CYP3A4, and lonafarnib is a sensitive CYP3A4 substrate. Lowered lonafarnib exposure may reduce its benefit, and labeling contraindicates its use with CYP3A inducers.
How serious is the interaction between Lonafarnib and Lorlatinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider an alternative to lorlatinib. Seek specialist advice if both are essential.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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