Drug reference
onabotulinumtoxinA
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (Miscellaneous(Musculoskeletal))
Mechanism of action
Neurotoxin from Clostridium botulinum; prevents ACh release from presynaptic membrane, causing temporary calming of muscle contractions by blocking the transmission of nerve impulses
Common side effects
- Dizziness
- Somnolence
- Urinary tract infections
- Urinary retension
- Residual urine volume
- Eyelid ptosis
- Brow ptosis
- Skin tightness
- Facial paresis
- Bacteriuria
Boxed warnings
- Effects of all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects These symptoms may include asthenia, generalized muscle weakness, diplopia, blurred vision, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence, and breathing difficulties These symptoms have been reported hours to weeks after injection Swallowing and breathing difficulties can be life threatening, and death have been reported The risk of symptoms is probably greatest in children treated for spasticity, but symptoms can also occur in…
Contraindications
- Intradetrusor injection: Urinary tract infection or urinary retention (post-void residual >200 mL, who are not routinely performing clean intermittent self-catheterizationwho are not routinely performing clean intermittent self-catheterization)
- Hypersensitivity Neuromuscular disease
- Infection at the proposed injection site
Related conditions
Frequently asked questions
What drug class is onabotulinumtoxinA?
onabotulinumtoxinA belongs to: Musculoskeletal.
How does onabotulinumtoxinA work?
Neurotoxin from Clostridium botulinum; prevents ACh release from presynaptic membrane, causing temporary calming of muscle contractions by blocking the transmission of nerve impulses
What are the common side effects of onabotulinumtoxinA?
Dizziness, Somnolence, Urinary tract infections, Urinary retension, Residual urine volume, Eyelid ptosis, Brow ptosis, Skin tightness, Facial paresis, Bacteriuria
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