Drug interactions
OnabotulinumtoxinA + Streptomycin
Severity: Major
OnabotulinumtoxinA and Streptomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides impair neuromuscular transmission and can add to the effect of botulinum toxin. This may cause excessive or generalized muscle weakness, including swallowing and breathing difficulty.
What this interaction means in plain words
OnabotulinumtoxinA and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
OnabotulinumtoxinA belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive neuromuscular blockade through reduced presynaptic acetylcholine release and weakened postsynaptic response.
What to do
Avoid concurrent use when possible. If unavoidable, monitor for generalized weakness, dysphagia and respiratory compromise.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Streptomycin
Other interactions of OnabotulinumtoxinA
- Amikacin + OnabotulinumtoxinA Major
- Gentamicin + OnabotulinumtoxinA Major
- Atracurium + OnabotulinumtoxinA Moderate
- Atropine + OnabotulinumtoxinA Moderate
- Baclofen + OnabotulinumtoxinA Moderate
- Benztropine + OnabotulinumtoxinA Moderate
Frequently asked questions
Can I take OnabotulinumtoxinA with Streptomycin?
MediHelp rates the interaction as major. OnabotulinumtoxinA and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides impair neuromuscular transmission and can add to the effect of botulinum toxin. This may cause excessive or generalized muscle weakness, including swallowing and breathing difficulty.
How serious is the interaction between OnabotulinumtoxinA and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when possible. If unavoidable, monitor for generalized weakness, dysphagia and respiratory compromise.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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