Drug interactions
bupropion + phenelzine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Hypertensive crisis/seizures; contraindicated.
Mechanism of action
MAOI + bupropion (NE/DA reuptake; lowers seizure threshold).
Clinical management
Contraindicated.
Drug reference
References
Frequently asked questions
Can I take bupropion with phenelzine?
The interaction is rated: Contraindicated. Hypertensive crisis/seizures; contraindicated.
How serious is the interaction between bupropion and phenelzine?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between bupropion and phenelzine managed?
Contraindicated.
Why do bupropion and phenelzine interact?
MAOI + bupropion (NE/DA reuptake; lowers seizure threshold).
Full monographs, dosing and an interaction checker in the MediHelp app
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