Drug reference
tranylcypromine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (MAOIs)
Mechanism of action
Nonselective monoamine oxidase inhibitor; may inhibit the enzyme monoamine oxidase, which is responsible for the breakdown of dopamine, serotonin, epinephrine, and norepinephrine, in turn causing an increase in endogenous concentrations of these neurotransmitters.
Common side effects
- Dizziness
- Drowsiness
- Headache
- Fatigue
- Orthostatic hypotension
- Weakness
- Sleep disturbance
Known interactions (40)
- amitriptyline + tranylcypromine Contraindicated
- atomoxetine + tranylcypromine Contraindicated
- brimonidine + tranylcypromine Contraindicated
- bupropion + tranylcypromine Contraindicated
- bupropion-naltrexone + tranylcypromine Contraindicated
- buspirone + tranylcypromine Contraindicated
- carbamazepine + tranylcypromine Contraindicated
- carbidopa-entacapone-levodopa + tranylcypromine Contraindicated
- carbidopa-levodopa + tranylcypromine Contraindicated
- citalopram + tranylcypromine Contraindicated
- clomipramine + tranylcypromine Contraindicated
- cyclobenzaprine + tranylcypromine Contraindicated
- cyproheptadine + tranylcypromine Contraindicated
- desipramine + tranylcypromine Contraindicated
- desvenlafaxine + tranylcypromine Contraindicated
- dextroamphetamine + tranylcypromine Contraindicated
- dextromethorphan + tranylcypromine Contraindicated
- dosulepin + tranylcypromine Contraindicated
- duloxetine + tranylcypromine Contraindicated
- entacapone + tranylcypromine Contraindicated
- epinephrine + tranylcypromine Contraindicated
- escitalopram + tranylcypromine Contraindicated
- fentanyl + tranylcypromine Contraindicated
- fluoxetine + tranylcypromine Contraindicated
- fluvoxamine + tranylcypromine Contraindicated
- imipramine + tranylcypromine Contraindicated
- isocarboxazid + tranylcypromine Contraindicated
- meperidine + tranylcypromine Contraindicated
- adrenaline-articaine + tranylcypromine Major
- almotriptan + tranylcypromine Major
- budesonide-formoterol + tranylcypromine Major
- dobutamine + tranylcypromine Major
- dopamine + tranylcypromine Major
- eletriptan + tranylcypromine Major
- formoterol + tranylcypromine Major
- frovatriptan + tranylcypromine Major
- ipratropium-salbutamol + tranylcypromine Major
- isoproterenol + tranylcypromine Major
- armodafinil + tranylcypromine Moderate
- caffeine + tranylcypromine Moderate
Related conditions
Frequently asked questions
What drug class is tranylcypromine?
tranylcypromine belongs to: Central Nervous System.
How does tranylcypromine work?
Nonselective monoamine oxidase inhibitor; may inhibit the enzyme monoamine oxidase, which is responsible for the breakdown of dopamine, serotonin, epinephrine, and norepinephrine, in turn causing an increase in endogenous concentrations of these neurotransmitters.
What are the common side effects of tranylcypromine?
Dizziness, Drowsiness, Headache, Fatigue, Orthostatic hypotension, Weakness, Sleep disturbance
Which drugs interact with tranylcypromine?
amitriptyline, atomoxetine, brimonidine, bupropion, bupropion-naltrexone, buspirone, carbamazepine, carbidopa-entacapone-levodopa, carbidopa-levodopa, citalopram, clomipramine, cyclobenzaprine, cyproheptadine, desipramine, desvenlafaxine
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