Drug reference
roflumilast
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Respiratory (PDE-4 inhibitor)
Mechanism of action
Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor which, due to its selective inhibition of the PDE4 isoenzyme, has potential antiinflammatory and antimodulatory effects in the pulmonary system.
Common side effects
- Headache
- Nausea
- Weight loss
- Diarrhea
Contraindications
- Hypersensitivity Moderate-to-severe liver impairment (Child-Pugh class B or C)
Known interactions (4)
- carbamazepine + roflumilast Major
- bosentan + roflumilast Moderate
- dexamethasone + roflumilast Moderate
- eslicarbazepine + roflumilast Moderate
Related conditions
Frequently asked questions
What drug class is roflumilast?
roflumilast belongs to: Respiratory.
How does roflumilast work?
Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor which, due to its selective inhibition of the PDE4 isoenzyme, has potential antiinflammatory and antimodulatory effects in the pulmonary system.
What are the common side effects of roflumilast?
Headache, Nausea, Weight loss, Diarrhea
Which drugs interact with roflumilast?
carbamazepine, bosentan, dexamethasone, eslicarbazepine
Full monographs, dosing and an interaction checker in the MediHelp app
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