Drug interactions
Mirtazapine + Selegiline
Severity: Contraindicated
Mirtazapine and Selegiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO-B inhibitor that becomes nonselective at higher doses or in transdermal form, and together with mirtazapine it may cause serotonin syndrome. The reaction can be severe and life-threatening.
What this interaction means in plain words
Mirtazapine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mirtazapine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Additive serotonergic and noradrenergic activity from MAO inhibition plus mirtazapine.
What to do
Avoid concurrent use. Leave at least 14 days after stopping selegiline before starting mirtazapine, and allow adequate washout of mirtazapine before starting selegiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline transdermal Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Selegiline?
MediHelp rates the interaction as contraindicated. Mirtazapine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is an MAO-B inhibitor that becomes nonselective at higher doses or in transdermal form, and together with mirtazapine it may cause serotonin syndrome. The reaction can be severe and life-threatening.
How serious is the interaction between Mirtazapine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Leave at least 14 days after stopping selegiline before starting mirtazapine, and allow adequate washout of mirtazapine before starting selegiline.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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