Drug interactions
Acyclovir + Sulphasalazine
Severity: Minor
Acyclovir and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs or their metabolites are organic anions handled by renal tubular secretion. Competition could slightly raise acyclovir exposure, but this is not recognised as clinically important.
What this interaction means in plain words
Acyclovir and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acyclovir belongs to Anti Virals; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Theoretical competition for renal tubular anionic transport (OAT).
What to do
No action needed in normal renal function. Monitor for acyclovir neurotoxicity if the patient has renal impairment or receives high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Acyclovir
- Acyclovir + Cidofovir Major
- Acyclovir + Polymyxin b Major
- Acyclovir + Talimogene laherparepvec Major
- Acyclovir + Adefovir Moderate
- Acyclovir + Amikacin Moderate
- Acyclovir + Amphotericin b Moderate
Frequently asked questions
Can I take Acyclovir with Sulphasalazine?
MediHelp rates the interaction as minor. Acyclovir and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs or their metabolites are organic anions handled by renal tubular secretion. Competition could slightly raise acyclovir exposure, but this is not recognised as clinically important.
How serious is the interaction between Acyclovir and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action needed in normal renal function. Monitor for acyclovir neurotoxicity if the patient has renal impairment or receives high doses.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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