Drug interactions
Asciminib + Sulphasalazine
Severity: Moderate
Asciminib and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asciminib may increase sulfasalazine exposure. This could increase sulfasalazine-related adverse effects.
What this interaction means in plain words
Asciminib and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asciminib belongs to Oncology; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of intestinal BCRP efflux increases sulfasalazine absorption.
What to do
Monitor for sulfasalazine adverse effects such as gastrointestinal intolerance and cytopenias. Consider dose reduction if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asciminib
Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Frequently asked questions
Can I take Asciminib with Sulphasalazine?
MediHelp rates the interaction as moderate. Asciminib and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asciminib may increase sulfasalazine exposure. This could increase sulfasalazine-related adverse effects.
How serious is the interaction between Asciminib and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sulfasalazine adverse effects such as gastrointestinal intolerance and cytopenias. Consider dose reduction if needed.
What other medicines interact with Asciminib?
MediHelp also lists interactions of Asciminib with, for example, Clarithromycin, Dihydroergotamine, Ergotamine. The full list is on the Asciminib page.
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