Drug interactions
Adenovirus types 4 and 7 live + Hydroxycarbamide
Severity: Major
Adenovirus types 4 and 7 live and Hydroxycarbamide: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyurea is myelosuppressive and can impair immune responses. A live oral adenovirus vaccine may therefore be less effective and could cause vaccine-related infection.
What this interaction means in plain words
Adenovirus types 4 and 7 live and Hydroxycarbamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Immunosuppression from hydroxyurea impairs the vaccine response and permits replication of live virus.
What to do
Avoid live vaccines during hydroxyurea therapy. Defer vaccination until immune recovery or use a non-live alternative where available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
- Betibeglogene autotemcel + Hydroxycarbamide Major
Frequently asked questions
Can I take Adenovirus types 4 and 7 live with Hydroxycarbamide?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Hydroxycarbamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Hydroxyurea is myelosuppressive and can impair immune responses. A live oral adenovirus vaccine may therefore be less effective and could cause vaccine-related infection.
How serious is the interaction between Adenovirus types 4 and 7 live and Hydroxycarbamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during hydroxyurea therapy. Defer vaccination until immune recovery or use a non-live alternative where available.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine, Stavudine, Axicabtagene ciloleucel. The full list is on the Hydroxycarbamide page.
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