Drug interactions
Aliskiren + Amiodarone
Severity: Minor
Aliskiren and Amiodarone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may modestly increase aliskiren exposure because both interact with P-glycoprotein. Clinical consequences, mainly additional blood pressure lowering, are expected to be small.
What this interaction means in plain words
Aliskiren and Amiodarone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aliskiren belongs to Cardiovascular; Amiodarone belongs to Cardiovascular.
Why it happens
Amiodarone inhibits P-glycoprotein efflux of aliskiren, increasing absorption.
What to do
No routine dose change is needed. Monitor blood pressure after starting or stopping amiodarone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Aliskiren
- Aliskiren + Amlodipine-benazepril Contraindicated
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Aliskiren + Amlodipine-perindopril Contraindicated
- Aliskiren + Amlodipine-valsartan Contraindicated
Frequently asked questions
Can I take Aliskiren with Amiodarone?
MediHelp rates the interaction as minor. Aliskiren and Amiodarone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may modestly increase aliskiren exposure because both interact with P-glycoprotein. Clinical consequences, mainly additional blood pressure lowering, are expected to be small.
How serious is the interaction between Aliskiren and Amiodarone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood pressure after starting or stopping amiodarone.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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