Drug interactions
Amiodarone + Dofetilide
Severity: Contraindicated
Amiodarone and Dofetilide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong cardiac repolarization. Combined use increases the risk of marked QT prolongation and torsades de pointes.
What this interaction means in plain words
Amiodarone and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amiodarone belongs to Cardiovascular; Dofetilide belongs to Cardiovascular.
Why it happens
Additive QT prolongation through potassium channel blockade.
What to do
Avoid concurrent use. Because of amiodarone's long half-life, seek specialist advice before starting dofetilide in a recently treated patient, with ECG monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
- Amiodarone + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
Other interactions of Dofetilide
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Chloroquine + Dofetilide Contraindicated
Frequently asked questions
Can I take Amiodarone with Dofetilide?
MediHelp rates the interaction as contraindicated. Amiodarone and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong cardiac repolarization. Combined use increases the risk of marked QT prolongation and torsades de pointes.
How serious is the interaction between Amiodarone and Dofetilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Because of amiodarone's long half-life, seek specialist advice before starting dofetilide in a recently treated patient, with ECG monitoring.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dronedarone. The full list is on the Amiodarone page.
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