Drug interactions
allopurinol + amoxicillin/clavulanate (Augmentin)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Concurrent use increases incidence of cutaneous rash with aminopenicillins (including amoxicillin). Typically maculopapular; rare severe hypersensitivity possible.
Mechanism of action
Unknown (non-pharmacokinetic); increased aminopenicillin-associated cutaneous reactions observed with allopurinol coadministration.
Clinical management
Prefer a non-aminopenicillin alternative when feasible. If coadministered, counsel and monitor closely for rash; discontinue antibiotic and/or allopurinol at first sign of hypersensitivity.
Drug reference
References
- Amoxicillin Prescribing Information — FDA Label
- Augmentin (amoxicillin/clavulanate potassium) Prescribing Information — FDA Label
- Allopurinol: Drug Interactions — Lexicomp
Frequently asked questions
Can I take allopurinol with amoxicillin/clavulanate (Augmentin)?
The interaction is rated: Moderate. Concurrent use increases incidence of cutaneous rash with aminopenicillins (including amoxicillin). Typically maculopapular; rare severe hypersensitivity possible.
How serious is the interaction between allopurinol and amoxicillin/clavulanate (Augmentin)?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between allopurinol and amoxicillin/clavulanate (Augmentin) managed?
Prefer a non-aminopenicillin alternative when feasible. If coadministered, counsel and monitor closely for rash; discontinue antibiotic and/or allopurinol at first sign of hypersensitivity.
Why do allopurinol and amoxicillin/clavulanate (Augmentin) interact?
Unknown (non-pharmacokinetic); increased aminopenicillin-associated cutaneous reactions observed with allopurinol coadministration.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.