Drug interactions
allopurinol + amoxicillin/clavulanate
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Concomitant use increases incidence of cutaneous rash with aminopenicillins (amoxicillin).
Mechanism of action
Unknown; non–PK mechanism suspected leading to higher rate of hypersensitivity-type skin eruptions.
Clinical management
Prefer a non-aminopenicillin if feasible. If used together, counsel and monitor closely for rash; discontinue antibiotic and/or allopurinol at first sign of cutaneous reaction.
Drug reference
References
- Zyloprim (allopurinol) Prescribing Information — FDA Label
- Amoxicillin and Clavulanate Potassium Prescribing Information — FDA Label
- Allopurinol: Drug Interactions — Lexicomp
Frequently asked questions
Can I take allopurinol with amoxicillin/clavulanate?
The interaction is rated: Moderate. Concomitant use increases incidence of cutaneous rash with aminopenicillins (amoxicillin).
How serious is the interaction between allopurinol and amoxicillin/clavulanate?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between allopurinol and amoxicillin/clavulanate managed?
Prefer a non-aminopenicillin if feasible. If used together, counsel and monitor closely for rash; discontinue antibiotic and/or allopurinol at first sign of cutaneous reaction.
Why do allopurinol and amoxicillin/clavulanate interact?
Unknown; non–PK mechanism suspected leading to higher rate of hypersensitivity-type skin eruptions.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.