Drug interactions
Allopurinol + Methotrexate
Severity: Moderate
Allopurinol and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Case reports describe severe bone marrow suppression when allopurinol is added to methotrexate, though evidence is limited and the interaction is not consistently seen.
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
Other interactions of Allopurinol
Drug class
- Allopurinol
- Genitourinary
- Methotrexate
- Oncology
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