Drug interactions
Alpelisib + Glipizide-metformin
Severity: Moderate
Alpelisib and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alpelisib may induce CYP2C9 and lower glipizide exposure, potentially weakening glucose control. Alpelisib itself commonly causes hyperglycemia, which can further complicate diabetes management.
What this interaction means in plain words
Alpelisib and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alpelisib belongs to Oncology; Glipizide-metformin belongs to Endocrine.
Why it happens
Alpelisib induces CYP2C9, increasing glipizide metabolism, and PI3K inhibition causes hyperglycemia.
What to do
Monitor blood glucose frequently during alpelisib therapy and increase antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Alpelisib
- Alpelisib + Carbamazepine Major
- Alpelisib + Phenytoin Major
- Alpelisib + Secobarbital Major
- Alpelisib + Apalutamide Moderate
- Alpelisib + Bosentan Moderate
- Alpelisib + Chlorpropamide Moderate
Frequently asked questions
Can I take Alpelisib with Glipizide-metformin?
MediHelp rates the interaction as moderate. Alpelisib and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alpelisib may induce CYP2C9 and lower glipizide exposure, potentially weakening glucose control. Alpelisib itself commonly causes hyperglycemia, which can further complicate diabetes management.
How serious is the interaction between Alpelisib and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during alpelisib therapy and increase antidiabetic therapy as needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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