Drug interactions
Alprazolam + Clozapine
Severity: Major
Alprazolam and Clozapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with clozapine can cause marked sedation, hypotension and, rarely, respiratory depression or collapse, particularly when clozapine is being started or increased.
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
Other interactions of Clozapine
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Drug class
- Alprazolam
- Central Nervous System
- Clozapine
- Central Nervous System
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