Drug interactions
Alprazolam + Doxepin
Severity: Moderate
Alprazolam and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining alprazolam with doxepin, a sedating tricyclic antidepressant, can intensify drowsiness, psychomotor impairment and anticholinergic-related confusion, particularly in older adults.
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
Drug class
- Alprazolam
- Central Nervous System
- Doxepin
- Dermatology
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