Drug interactions
Alprazolam + Fleroxacin
Severity: Minor
Alprazolam and Fleroxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fleroxacin is a fluoroquinolone with weak effects on hepatic oxidative metabolism and may slightly raise alprazolam levels. Clinical relevance is probably small.
What this interaction means in plain words
Alprazolam and Fleroxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible modest inhibition of hepatic metabolism of alprazolam; the mechanism is not firmly established.
What to do
No routine dose change is needed; monitor for increased sedation when starting fleroxacin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Fleroxacin?
MediHelp rates the interaction as minor. Alprazolam and Fleroxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fleroxacin is a fluoroquinolone with weak effects on hepatic oxidative metabolism and may slightly raise alprazolam levels. Clinical relevance is probably small.
How serious is the interaction between Alprazolam and Fleroxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for increased sedation when starting fleroxacin.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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