Drug interactions
Alprazolam + Gabapentin enacarbil
Severity: Moderate
Alprazolam and Gabapentin enacarbil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil, a gabapentin prodrug, adds to the sedative and respiratory depressant effects of alprazolam. Risk of marked drowsiness and respiratory depression is greater in older or compromised patients.
What this interaction means in plain words
Alprazolam and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive CNS depression via pharmacodynamic synergism.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, especially in patients with respiratory disease or the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Gabapentin enacarbil?
MediHelp rates the interaction as moderate. Alprazolam and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin enacarbil, a gabapentin prodrug, adds to the sedative and respiratory depressant effects of alprazolam. Risk of marked drowsiness and respiratory depression is greater in older or compromised patients.
How serious is the interaction between Alprazolam and Gabapentin enacarbil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, especially in patients with respiratory disease or the elderly.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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