Drug interactions
Alprazolam + Givinostat
Severity: Minor
Alprazolam and Givinostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat is a weak CYP3A4 inhibitor and may slightly raise alprazolam exposure. The clinical effect is likely small but could increase sedation.
What this interaction means in plain words
Alprazolam and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alprazolam belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Why it happens
Weak inhibition of CYP3A4-mediated alprazolam metabolism by givinostat.
What to do
Monitor for increased drowsiness and reduce the alprazolam dose if sedation develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Other interactions of Givinostat
- Abiraterone + Givinostat Major
Frequently asked questions
Can I take Alprazolam with Givinostat?
MediHelp rates the interaction as minor. Alprazolam and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat is a weak CYP3A4 inhibitor and may slightly raise alprazolam exposure. The clinical effect is likely small but could increase sedation.
How serious is the interaction between Alprazolam and Givinostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness and reduce the alprazolam dose if sedation develops.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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