Drug interactions
Alprazolam + Griseofulvin
Severity: Minor
Alprazolam and Griseofulvin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a weak inducer of CYP3A4 and may lower alprazolam concentrations. Reduced anxiolytic or antipanic effect or withdrawal symptoms could occur.
What this interaction means in plain words
Alprazolam and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alprazolam belongs to Central Nervous System; Griseofulvin belongs to Anti Fungals.
Why it happens
Induction of CYP3A4-mediated alprazolam metabolism by griseofulvin.
What to do
Monitor for reduced alprazolam efficacy during griseofulvin therapy and adjust the dose if needed. Reassess dose after griseofulvin is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Griseofulvin?
MediHelp rates the interaction as minor. Alprazolam and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a weak inducer of CYP3A4 and may lower alprazolam concentrations. Reduced anxiolytic or antipanic effect or withdrawal symptoms could occur.
How serious is the interaction between Alprazolam and Griseofulvin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced alprazolam efficacy during griseofulvin therapy and adjust the dose if needed. Reassess dose after griseofulvin is stopped.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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