Drug interactions
Alprazolam + Isavuconazonium
Severity: Moderate
Alprazolam and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active form of isavuconazonium, inhibits CYP3A4 and can increase alprazolam exposure, causing greater sedation. The effect is moderate.
What this interaction means in plain words
Alprazolam and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Isavuconazonium belongs to Anti Fungals.
Why it happens
Isavuconazole is a moderate CYP3A4 inhibitor that decreases alprazolam clearance.
What to do
Monitor for oversedation and consider lowering the alprazolam dose while on isavuconazonium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Isavuconazonium?
MediHelp rates the interaction as moderate. Alprazolam and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active form of isavuconazonium, inhibits CYP3A4 and can increase alprazolam exposure, causing greater sedation. The effect is moderate.
How serious is the interaction between Alprazolam and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider lowering the alprazolam dose while on isavuconazonium.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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