Drug interactions
Alprazolam + Larotrectinib
Severity: Minor
Alprazolam and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib may modestly inhibit CYP3A4 and could raise alprazolam concentrations. Any increase in sedation is expected to be small.
What this interaction means in plain words
Alprazolam and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alprazolam belongs to Central Nervous System; Larotrectinib belongs to Oncology.
Why it happens
Larotrectinib is a CYP3A4 substrate with possible weak inhibition of CYP3A4, reducing alprazolam clearance.
What to do
Monitor for excess drowsiness after starting larotrectinib and lower the alprazolam dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Larotrectinib?
MediHelp rates the interaction as minor. Alprazolam and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib may modestly inhibit CYP3A4 and could raise alprazolam concentrations. Any increase in sedation is expected to be small.
How serious is the interaction between Alprazolam and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness after starting larotrectinib and lower the alprazolam dose if needed.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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