Drug interactions
Alprazolam + Letermovir
Severity: Moderate
Alprazolam and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A and can increase concentrations of CYP3A substrates such as alprazolam. This may enhance sedation, dizziness and cognitive impairment. The effect is generally moderate in size.
What this interaction means in plain words
Alprazolam and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4, reducing the metabolic clearance of alprazolam.
What to do
Monitor for increased sedation and consider reducing the alprazolam dose during letermovir therapy. Reassess the dose when letermovir is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Letermovir?
MediHelp rates the interaction as moderate. Alprazolam and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A and can increase concentrations of CYP3A substrates such as alprazolam. This may enhance sedation, dizziness and cognitive impairment. The effect is generally moderate in size.
How serious is the interaction between Alprazolam and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and consider reducing the alprazolam dose during letermovir therapy. Reassess the dose when letermovir is stopped.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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