Drug interactions
Alprazolam + Lofepramine
Severity: Moderate
Alprazolam and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, so concurrent use may increase drowsiness and psychomotor impairment. Alprazolam may also modestly raise tricyclic concentrations, though this is not well established for lofepramine.
What this interaction means in plain words
Alprazolam and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible minor metabolic inhibition.
What to do
Monitor for excessive sedation, dizziness and anticholinergic effects. Reduce doses if impairment occurs and counsel patients on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Lofepramine?
MediHelp rates the interaction as moderate. Alprazolam and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, so concurrent use may increase drowsiness and psychomotor impairment. Alprazolam may also modestly raise tricyclic concentrations, though this is not well established for lofepramine.
How serious is the interaction between Alprazolam and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and anticholinergic effects. Reduce doses if impairment occurs and counsel patients on driving.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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