Drug interactions
Alprazolam + Lomitapide
Severity: Minor
Alprazolam and Lomitapide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alprazolam is a weak CYP3A4 inhibitor at most and could slightly raise lomitapide exposure, which is a CYP3A4 substrate. Higher lomitapide exposure may increase gastrointestinal effects and liver enzyme elevations. The clinical effect is likely small.
What this interaction means in plain words
Alprazolam and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alprazolam belongs to Central Nervous System; Lomitapide belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition by alprazolam reducing lomitapide clearance.
What to do
Monitor liver enzymes and gastrointestinal tolerability per standard lomitapide monitoring. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to see why Alprazolam and Lomitapide interact, what to do about it, and the sources.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Lomitapide?
MediHelp rates the interaction as minor. Alprazolam and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Alprazolam is a weak CYP3A4 inhibitor at most and could slightly raise lomitapide exposure, which is a CYP3A4 substrate. Higher lomitapide exposure may increase gastrointestinal effects and liver enzyme elevations. The clinical effect is likely small.
How serious is the interaction between Alprazolam and Lomitapide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerability per standard lomitapide monitoring. No dose change is usually needed.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
