Drug interactions
Alprazolam + Metoclopramide intranasal
Severity: Moderate
Alprazolam and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause CNS effects such as drowsiness, dizziness and extrapyramidal symptoms, which may be additive with the sedation of alprazolam. The interaction is generally of limited magnitude.
What this interaction means in plain words
Alprazolam and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects; metoclopramide's central dopamine antagonism adds to benzodiazepine sedation.
What to do
Monitor for excessive drowsiness and warn patients about driving or operating machinery. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Alprazolam and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause CNS effects such as drowsiness, dizziness and extrapyramidal symptoms, which may be additive with the sedation of alprazolam. The interaction is generally of limited magnitude.
How serious is the interaction between Alprazolam and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness and warn patients about driving or operating machinery. Use the lowest effective doses.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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