Drug interactions
Alprazolam + Nabilone
Severity: Moderate
Alprazolam and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone is a synthetic cannabinoid that causes drowsiness, dizziness and impaired judgment, and alprazolam is a benzodiazepine with similar effects. Together they can cause excessive sedation, psychomotor impairment and, at higher doses, respiratory depression and confusion.
What this interaction means in plain words
Alprazolam and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and warn patients about driving and operating machinery. Monitor for excess sedation, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
- Alfentanil + Nabilone Major
Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Nabilone?
MediHelp rates the interaction as moderate. Alprazolam and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone is a synthetic cannabinoid that causes drowsiness, dizziness and impaired judgment, and alprazolam is a benzodiazepine with similar effects. Together they can cause excessive sedation, psychomotor impairment and, at higher doses, respiratory depression and confusion.
How serious is the interaction between Alprazolam and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn patients about driving and operating machinery. Monitor for excess sedation, especially in older patients.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil. The full list is on the Nabilone page.
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