Drug interactions
Alprazolam + Nifedipine
Severity: Minor
Alprazolam and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a weak CYP3A4 inhibitor and may modestly increase alprazolam levels. This could add to sedation and psychomotor impairment.
What this interaction means in plain words
Alprazolam and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alprazolam belongs to Central Nervous System; Nifedipine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated alprazolam metabolism.
What to do
Monitor for excess sedation and reduce the alprazolam dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
- Amifostine + Nifedipine Major
Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Nifedipine?
MediHelp rates the interaction as minor. Alprazolam and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is a weak CYP3A4 inhibitor and may modestly increase alprazolam levels. This could add to sedation and psychomotor impairment.
How serious is the interaction between Alprazolam and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduce the alprazolam dose if needed.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine. The full list is on the Nifedipine page.
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