Drug interactions
Alprazolam + Orphenadrine
Severity: Moderate
Alprazolam and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine has sedating and anticholinergic properties that add to the central nervous system depression produced by alprazolam. Drowsiness, dizziness, confusion and impaired psychomotor performance may be more pronounced, especially in older adults.
What this interaction means in plain words
Alprazolam and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects through pharmacodynamic synergy.
What to do
Use the lowest effective doses and warn patients to avoid driving or hazardous tasks until response is known. Monitor older patients closely for oversedation, confusion and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Orphenadrine?
MediHelp rates the interaction as moderate. Alprazolam and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine has sedating and anticholinergic properties that add to the central nervous system depression produced by alprazolam. Drowsiness, dizziness, confusion and impaired psychomotor performance may be more pronounced, especially in older adults.
How serious is the interaction between Alprazolam and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn patients to avoid driving or hazardous tasks until response is known. Monitor older patients closely for oversedation, confusion and falls.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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