Drug interactions
Alprazolam + Quazepam
Severity: Major
Alprazolam and Quazepam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two benzodiazepines produces additive sedation, psychomotor impairment and respiratory depression without added therapeutic benefit. Quazepam has long-acting active metabolites, so effects can persist.
What this interaction means in plain words
Alprazolam and Quazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive GABA-A receptor mediated CNS depression.
What to do
Avoid concurrent use of two benzodiazepines and consolidate to a single agent where possible. If overlap is unavoidable, use minimal doses and monitor sedation and breathing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Quazepam?
MediHelp rates the interaction as major. Alprazolam and Quazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two benzodiazepines produces additive sedation, psychomotor impairment and respiratory depression without added therapeutic benefit. Quazepam has long-acting active metabolites, so effects can persist.
How serious is the interaction between Alprazolam and Quazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two benzodiazepines and consolidate to a single agent where possible. If overlap is unavoidable, use minimal doses and monitor sedation and breathing.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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