Drug interactions
Alprazolam + Quinupristin / dalfopristin
Severity: Moderate
Alprazolam and Quinupristin / dalfopristin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise alprazolam concentrations, increasing and prolonging sedation and psychomotor impairment. The effect is established for other CYP3A4 substrates and predicted for alprazolam.
What this interaction means in plain words
Alprazolam and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated alprazolam metabolism.
What to do
Monitor for excessive sedation and consider reducing the alprazolam dose during the antibiotic course. Return to the usual dose after the antibiotic is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Alprazolam and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may raise alprazolam concentrations, increasing and prolonging sedation and psychomotor impairment. The effect is established for other CYP3A4 substrates and predicted for alprazolam.
How serious is the interaction between Alprazolam and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider reducing the alprazolam dose during the antibiotic course. Return to the usual dose after the antibiotic is stopped.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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