Drug interactions
Alprazolam + Ramelteon
Severity: Minor
Alprazolam and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon is a mild sedative-hypnotic and may add somewhat to alprazolam drowsiness. The effect is generally modest, and ramelteon does not substantially potentiate benzodiazepine effects.
What this interaction means in plain words
Alprazolam and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alprazolam belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Mild additive sedation through melatonin receptor agonism and GABA-A potentiation, without a pharmacokinetic interaction.
What to do
Counsel on next-day drowsiness and avoid driving if impaired. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Other interactions of Ramelteon
- Alfentanil + Ramelteon Moderate
Frequently asked questions
Can I take Alprazolam with Ramelteon?
MediHelp rates the interaction as minor. Alprazolam and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon is a mild sedative-hypnotic and may add somewhat to alprazolam drowsiness. The effect is generally modest, and ramelteon does not substantially potentiate benzodiazepine effects.
How serious is the interaction between Alprazolam and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on next-day drowsiness and avoid driving if impaired. No routine dose change is needed.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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