Drug interactions
Alprazolam + Rucaparib
Severity: Minor
Alprazolam and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and may modestly increase alprazolam exposure. The result may be somewhat greater sedation, though the effect is usually limited.
What this interaction means in plain words
Alprazolam and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alprazolam belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib weakly inhibits CYP3A4, slightly reducing alprazolam metabolism.
What to do
Watch for increased drowsiness or psychomotor impairment and reduce the alprazolam dose if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Other interactions of Rucaparib
- Alfuzosin + Rucaparib Moderate
Frequently asked questions
Can I take Alprazolam with Rucaparib?
MediHelp rates the interaction as minor. Alprazolam and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and may modestly increase alprazolam exposure. The result may be somewhat greater sedation, though the effect is usually limited.
How serious is the interaction between Alprazolam and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for increased drowsiness or psychomotor impairment and reduce the alprazolam dose if symptoms appear.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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