Drug interactions
Alprazolam + Sage
Severity: Minor
Alprazolam and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage may have mild sedative properties and could theoretically add to the sedation caused by alprazolam. Clinical evidence is scant.
What this interaction means in plain words
Alprazolam and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive CNS depressant effect; the mechanism is not established.
What to do
Advise patients to report increased drowsiness when taking sage supplements with alprazolam, and stop the herb if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Sage?
MediHelp rates the interaction as minor. Alprazolam and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage may have mild sedative properties and could theoretically add to the sedation caused by alprazolam. Clinical evidence is scant.
How serious is the interaction between Alprazolam and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report increased drowsiness when taking sage supplements with alprazolam, and stop the herb if it occurs.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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