Drug interactions
Alprazolam + Sevoflurane
Severity: Moderate
Alprazolam and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines reduce the anesthetic requirement for volatile agents, and together they can deepen sedation and respiratory and cardiovascular depression. This is relevant for patients taking alprazolam before surgery.
What this interaction means in plain words
Alprazolam and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS depression.
What to do
Inform the anesthesia team about benzodiazepine use and titrate sevoflurane to effect with continuous monitoring. Do not stop chronic alprazolam abruptly before surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Sevoflurane?
MediHelp rates the interaction as moderate. Alprazolam and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines reduce the anesthetic requirement for volatile agents, and together they can deepen sedation and respiratory and cardiovascular depression. This is relevant for patients taking alprazolam before surgery.
How serious is the interaction between Alprazolam and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about benzodiazepine use and titrate sevoflurane to effect with continuous monitoring. Do not stop chronic alprazolam abruptly before surgery.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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