Drug interactions
Alprazolam + Suvorexant
Severity: Moderate
Alprazolam and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the central nervous system, so combined use can cause additive sedation and impaired next-day alertness, coordination and memory. The risk of falls and impaired driving increases.
What this interaction means in plain words
Alprazolam and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and orexin receptor antagonism.
What to do
Avoid combining where possible, or use the lowest effective doses of each and counsel against driving or hazardous tasks. Reduce the dose of one or both if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Suvorexant?
MediHelp rates the interaction as moderate. Alprazolam and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the central nervous system, so combined use can cause additive sedation and impaired next-day alertness, coordination and memory. The risk of falls and impaired driving increases.
How serious is the interaction between Alprazolam and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or use the lowest effective doses of each and counsel against driving or hazardous tasks. Reduce the dose of one or both if excessive sedation occurs.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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