Drug interactions
Alprazolam + Tazemetostat
Severity: Minor
Alprazolam and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and may lower alprazolam concentrations and effect. Alprazolam is not a significant CYP3A4 inhibitor, so the reverse effect on tazemetostat is not clinically meaningful.
What this interaction means in plain words
Alprazolam and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alprazolam belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by tazemetostat increases alprazolam clearance.
What to do
Monitor response to alprazolam and adjust the dose if efficacy is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Tazemetostat?
MediHelp rates the interaction as minor. Alprazolam and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak-to-moderate CYP3A4 inducer and may lower alprazolam concentrations and effect. Alprazolam is not a significant CYP3A4 inhibitor, so the reverse effect on tazemetostat is not clinically meaningful.
How serious is the interaction between Alprazolam and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to alprazolam and adjust the dose if efficacy is reduced.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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