Drug interactions
Alprazolam + Tecovirimat
Severity: Minor
Alprazolam and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may modestly lower alprazolam exposure. The effect is probably small and temporary during the short treatment course.
What this interaction means in plain words
Alprazolam and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alprazolam belongs to Central Nervous System; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 increases alprazolam metabolism.
What to do
Monitor for reduced anxiolytic effect during tecovirimat therapy; dose changes are rarely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Tecovirimat?
MediHelp rates the interaction as minor. Alprazolam and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and may modestly lower alprazolam exposure. The effect is probably small and temporary during the short treatment course.
How serious is the interaction between Alprazolam and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced anxiolytic effect during tecovirimat therapy; dose changes are rarely needed.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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