Drug interactions
Alprazolam + Temazepam
Severity: Major
Alprazolam and Temazepam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two benzodiazepines together produces additive sedation, psychomotor impairment and respiratory depression with no added therapeutic benefit. Falls and next-day impairment are particular concerns in older adults.
What this interaction means in plain words
Alprazolam and Temazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alprazolam belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor mediated CNS depression.
What to do
Avoid duplicate benzodiazepine therapy and use one agent at the lowest effective dose. If overlap is unavoidable, monitor sedation and breathing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Temazepam?
MediHelp rates the interaction as major. Alprazolam and Temazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two benzodiazepines together produces additive sedation, psychomotor impairment and respiratory depression with no added therapeutic benefit. Falls and next-day impairment are particular concerns in older adults.
How serious is the interaction between Alprazolam and Temazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate benzodiazepine therapy and use one agent at the lowest effective dose. If overlap is unavoidable, monitor sedation and breathing.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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