Drug interactions
Alprazolam + Yohimbine
Severity: Minor
Alprazolam and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects that may counter the calming effects of alprazolam. The net effect is unpredictable and clinical significance is probably small.
What this interaction means in plain words
Alprazolam and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects: yohimbine increases noradrenergic activity while alprazolam enhances GABAergic inhibition.
What to do
Be aware that alprazolam may be less effective for anxiety or sedation in patients taking yohimbine. Reassess the response and avoid raising the benzodiazepine dose solely to offset it.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to see why Alprazolam and Yohimbine interact, what to do about it, and the sources.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Yohimbine?
MediHelp rates the interaction as minor. Alprazolam and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects that may counter the calming effects of alprazolam. The net effect is unpredictable and clinical significance is probably small.
How serious is the interaction between Alprazolam and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware that alprazolam may be less effective for anxiety or sedation in patients taking yohimbine. Reassess the response and avoid raising the benzodiazepine dose solely to offset it.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
