Drug interactions
Alprazolam + Ziconotide
Severity: Moderate
Alprazolam and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intrathecal ziconotide commonly causes cognitive impairment, drowsiness and reduced alertness. Concomitant alprazolam may add to these CNS effects.
What this interaction means in plain words
Alprazolam and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depression from N-type calcium channel blockade by ziconotide and GABA-A potentiation by alprazolam.
What to do
Monitor for sedation, confusion and altered mental status and reduce the benzodiazepine dose if needed. Consider ziconotide dose reduction or interruption if cognitive effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Ziconotide?
MediHelp rates the interaction as moderate. Alprazolam and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intrathecal ziconotide commonly causes cognitive impairment, drowsiness and reduced alertness. Concomitant alprazolam may add to these CNS effects.
How serious is the interaction between Alprazolam and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and altered mental status and reduce the benzodiazepine dose if needed. Consider ziconotide dose reduction or interruption if cognitive effects emerge.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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