Drug interactions
Alteplase + Rivaroxaban
Severity: Major
Alteplase and Rivaroxaban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thrombolysis with alteplase in a patient who is taking rivaroxaban carries a markedly increased risk of major bleeding, including intracranial hemorrhage.
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to see why Alteplase and Rivaroxaban interact, what to do about it, and the sources.
- Mechanism of action
- Clinical management
- Evidence level
Free 14-day trial. No card needed.
Other interactions of Rivaroxaban
Other interactions of Alteplase
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
