Drug reference
rivaroxaban
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Thrombotics)
Mechanism of action
Factor Xa inhibitor that inhibits platelet activation by blocking the active site of factor Xa without requiring a cofactor (eg, antithrombin III) for activity Blood coagulation cascade is dependent on the activation of factor X to factor Xa via the intrinsic and extrinsic pathways, which play a central role in the blood coagulation cascade
Common side effects
- Pruritus
- Dizziness
- Hematoma
- Back pain
- Wound secretion
- Abdominal pain
Boxed warnings
- Epidural or spinal hematomas May occur in patients who are anticoagulated and are receiving neuraxial anesthesia or undergoing spinal puncture; consider the benefits and risks in anticoagulated patients who are candidates for neuraxial intervention; optimal timing between therapy administration and neuraxial procedures is not known These hematomas may result in long-term or permanent paralysis; consider these risks when scheduling patients for spinal procedures Factors increasing risk: Indwelling epidural catheters, coadministration with other drugs that affect hemostasis, such as no…
Contraindications
- Hypersensitivity Active pathological bleeding Patients who have had transcatheter aortic valve replacement (Tavr)
Known interactions (5)
- ketoconazole + rivaroxaban Contraindicated
- Celecoxib + rivaroxaban Major
- enzalutamide + rivaroxaban Major
- fondaparinux + rivaroxaban Major
- rifampin + rivaroxaban Major
Related conditions
Frequently asked questions
What drug class is rivaroxaban?
rivaroxaban belongs to: Cardiovascular.
How does rivaroxaban work?
Factor Xa inhibitor that inhibits platelet activation by blocking the active site of factor Xa without requiring a cofactor (eg, antithrombin III) for activity Blood coagulation cascade is dependent on the activation of factor X to factor Xa via the intrinsic and extrinsic pathways, which play a central role in the blood coagulation cascade
What are the common side effects of rivaroxaban?
Pruritus, Dizziness, Hematoma, Back pain, Wound secretion, Abdominal pain
Which drugs interact with rivaroxaban?
ketoconazole, Celecoxib, enzalutamide, fondaparinux, rifampin
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