Drug interactions
Aluminum hydroxide + Bictegravir
Severity: Moderate
Aluminum hydroxide and Bictegravir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aluminum-containing antacids bind bictegravir in the gut and lower its absorption. Reduced exposure may compromise viral suppression and encourage resistance.
What this interaction means in plain words
Aluminum hydroxide and Bictegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of bictegravir by polyvalent aluminum cations in the gastrointestinal tract reduces its absorption.
What to do
Give bictegravir at least 2 hours before aluminum antacids under fasting conditions, and avoid taking it simultaneously or within 2 hours after the antacid. Alternatively, use a non-cation acid-reducing option.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Bictegravir?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Bictegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aluminum-containing antacids bind bictegravir in the gut and lower its absorption. Reduced exposure may compromise viral suppression and encourage resistance.
How serious is the interaction between Aluminum hydroxide and Bictegravir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give bictegravir at least 2 hours before aluminum antacids under fasting conditions, and avoid taking it simultaneously or within 2 hours after the antacid. Alternatively, use a non-cation acid-reducing option.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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