Drug interactions
Aluminum hydroxide + Cabotegravir
Severity: Moderate
Aluminum hydroxide and Cabotegravir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aluminum antacids can reduce the absorption of oral cabotegravir by binding it in the gut. Lower concentrations could weaken virologic control.
What this interaction means in plain words
Aluminum hydroxide and Cabotegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Cabotegravir belongs to Anti Virals.
Why it happens
Polyvalent aluminum cations chelate cabotegravir in the gastrointestinal tract, decreasing absorption.
What to do
Take oral cabotegravir at least 2 hours before or 4 hours after the antacid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Cabotegravir?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Cabotegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aluminum antacids can reduce the absorption of oral cabotegravir by binding it in the gut. Lower concentrations could weaken virologic control.
How serious is the interaction between Aluminum hydroxide and Cabotegravir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take oral cabotegravir at least 2 hours before or 4 hours after the antacid.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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