Drug interactions
Aluminum hydroxide + Cefdinir
Severity: Moderate
Aluminum hydroxide and Cefdinir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aluminum- and magnesium-containing antacids reduce cefdinir absorption by roughly a third, risking subtherapeutic levels. Iron products have a similar effect.
What this interaction means in plain words
Aluminum hydroxide and Cefdinir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Cefdinir belongs to Anti Bacterial.
Why it happens
Cefdinir forms poorly absorbed complexes with polyvalent cations in the gut.
What to do
Give cefdinir at least 2 hours before or after aluminum-containing antacids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Cefdinir?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Cefdinir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aluminum- and magnesium-containing antacids reduce cefdinir absorption by roughly a third, risking subtherapeutic levels. Iron products have a similar effect.
How serious is the interaction between Aluminum hydroxide and Cefdinir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give cefdinir at least 2 hours before or after aluminum-containing antacids.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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